The glutathione reductase (GSR) polymorphisms (rs1002149 and rs8191009) and diabetic retinopathy in Slovenian subjects with type 2 diabetes mellitus

The present work was carried out to evaluate a possible association between two polymorphisms (rs1002149 and rs8191009) in the GSR gene coding for antioxidant enzyme, and DR in 804 unrelated Slovene subjects (Caucasians) with T2DM. No differences were observed in genotype distribution between the two groups for either polymorphism in the GSR gene. No significant differences in serum 8-OHdG levels among subjects with DR stratified according to three possible genotypes were observed. In our study, we did not demonstrate an association between either rs1002149 or rs8191009 and DR in subjects with T2DM. Correspondence to: Daniel Petrovič, MD, PhD, Institute of Histology and Embryology, Medical Faculty of Ljubljana, Korytkova 2, SI-1105 Ljubljana, Slovenia, Tel: +386 1 543 7367, Fax: +386 1 543 7361, E-mail: [email protected]